AlphaFold 3 LFDI Audit Record

This folder preserves a complete audit packet for the paper:

"Accurate structure prediction of biomolecular interactions with AlphaFold 3"
Josh Abramson et al.
Nature, Vol. 630, 13 June 2024
DOI: 10.1038/s41586-024-07487-w

Purpose:
This archive exists to preserve the original academic paper, the Life-First Decision Invariant framework paper, and the LFDI alignment audit applied to AlphaFold 3 as a single public record.

Contents:
alphafold_3_s41586-024-07487-w.pdf
- Original AlphaFold 3 paper.

life_is_most_important_v2.0.1.pdf
- Life-First / LFDI framework paper by David Wishengrad.

lfdi_alignment_audit_alphafold_3.pdf
- LFDI audit of the AlphaFold 3 paper.


LFDI Framework:
Life is Most Important in Life is The Most Important Truth in Life
A Foundational Proof for Alignment, Identity, and the Cure of Needless Suffering
David Wishengrad
Version 2.0.1
Primary DOI: 10.21428/4831231e.8c4c6c8f
PhilPapers record: https://philpapers.org/rec/WISLIM

Audit Claim:
AlphaFold 3 is a life-affecting biomolecular AI system because its outputs may affect medicine, drug discovery, biological research, and decisions involving living systems. The LFDI audit asks whether the system is governed by a non-substitutable Life-First constraint, rather than by structural accuracy, prediction performance, commercial value, scientific speed, or technical capability alone.

Rights / Attribution:
The original paper remains the work of its original authors and publisher. It is included here only for scholarly audit, commentary, citation, and preservation context. All attribution should remain with the original authors.

Created by:
David Wishengrad 
July 20, 2026